h3/Acidic Calponin: An Actin-binding Protein That Controls Extracellular Signal-regulated Kinase 1/2 Activity in Nonmuscle Cells

@inproceedings{Appel2010h3AcidicCA,
  title={h3/Acidic Calponin: An Actin-binding Protein That Controls Extracellular Signal-regulated Kinase 1/2 Activity in Nonmuscle Cells},
  author={Sarah D Appel and Philip G. Allen and Susanne Vetterkind and Jian-Ping Jin and Kathleen G Morgan},
  booktitle={Molecular biology of the cell},
  year={2010}
}
Migration of fibroblasts is important in wound healing. Here, we demonstrate a role and a mechanism for h3/acidic calponin (aCaP, CNN3) in REF52.2 cell motility, a fibroblast line rich in actin filaments. We show that the actin-binding protein h3/acidic calponin associates with stress fibers in the absence of stimulation but is targeted to the cell cortex and podosome-like structures after stimulation with a phorbol ester, phorbol-12,13-dibutyrate (PDBu). By coimmunoprecipitation and… CONTINUE READING
Blog posts, news articles and tweet counts and IDs sourced by
Altmetric.com