gro-beta, a -C-X-C- chemokine, is an angiogenesis inhibitor that suppresses the growth of Lewis lung carcinoma in mice

@article{Cao1995grobetaA,
  title={gro-beta, a -C-X-C- chemokine, is an angiogenesis inhibitor that suppresses the growth of Lewis lung carcinoma in mice},
  author={Yi lin Cao and Catherine C Chen and James A. Weatherbee and M. T. S. Tsang and Judah M Folkman},
  journal={The Journal of Experimental Medicine},
  year={1995},
  volume={182},
  pages={2069 - 2077}
}
We have found that two chemokines, recombinant gro-alpha and gro-beta, specifically inhibit growth factor-stimulated proliferation of capillary endothelial cells in a dose-dependent manner, whereas gro-gamma has no inhibitory effect. In vivo, gro-beta inhibits blood vessel formation in the chicken chorioallantoic membrane assay. It is sufficiently potent to effectively suppress basic fibroblast growth factor-induced corneal neovascularization after systemic administration in mice. Further, gro… CONTINUE READING

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