gp130 cytokines are positive signals triggering changes in gene expression and axon outgrowth in peripheral neurons following injury

@inproceedings{Zigmond2011gp130CA,
  title={gp130 cytokines are positive signals triggering changes in gene expression and axon outgrowth in peripheral neurons following injury},
  author={Richard E Zigmond},
  booktitle={Front. Mol. Neurosci.},
  year={2011}
}
Adult peripheral neurons, in contrast to adult central neurons, are capable of regeneration after axonal damage. Much attention has focused on the changes that accompany this regeneration in two places, the distal nerve segment (where phagocytosis of axonal debris, changes in the surface properties of Schwann cells, and induction of growth factors and cytokines occur) and the neuronal cell body (where dramatic changes in cell morphology and gene expression occur). The changes in the axotomized… CONTINUE READING

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