gp130 at the nexus of inflammation, autoimmunity, and cancer.

  title={gp130 at the nexus of inflammation, autoimmunity, and cancer.},
  author={Jonathan S. Silver and Christopher A Hunter},
  journal={Journal of leukocyte biology},
  volume={88 6},
Glycoprotein 130 (gp130) is a shared receptor utilized by several related cytokines, including IL-6, IL-11, IL-27, Leukemia Inhibitory Factor (LIF), Oncostatin M (OSM), Ciliary Neurotrophic Factor (CNTF), Cardiotrophin 1 (CT-1) and Cardiotrophin-like Cytokine (CLC). Gp130 plays critical roles during development and gp130-deficient mice are embryonically lethal. However, the best characterized facet of this receptor and its associated cytokines is the ability to promote or suppress inflammation… CONTINUE READING
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