gp130 and c-Kit signalings synergize for ex vivo expansion of human primitive hemopoietic progenitor cells.

@article{Sui1995gp130AC,
  title={gp130 and c-Kit signalings synergize for ex vivo expansion of human primitive hemopoietic progenitor cells.},
  author={Xingwei Sui and Kohichiro Tsuji and Ryuhei Tanaka and Sakura Tajima and Kenji Muraoka and Yasuhiro Ebihara and Kazuya Ikebuchi and Kiyoshi Yasukawa and Tetsuya Taga and Tadamitsu Kishimoto},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 7},
  pages={
          2859-63
        }
}
gp130, a signal-transducing receptor component of interleukin 6 (IL-6), associates with an IL-6 and IL-6 receptor (IL-6) complex and transduces signals. To examine the role of gp130 signaling in the expansion of human hemopoietic progenitor cells, we tested the effects of a recombinant soluble human IL-6 receptor (sIL-6R) and/or IL-6 in combination with other cytokines on purified human umbilical cord blood CD34+ cells, using methylcellulose clonal assay and suspension culture in the presence… CONTINUE READING

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Analysis of interleukin 6 receptor and gp130 expressions and proliferative capability of human CD34+ cells

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  • 1996
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Role of glycoprotein 130 and c-Kit signaling in proliferation and differentiation of human hematopoietic progenitor cells

  • Cancer Chemotherapy and Pharmacology
  • 1996
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