gp120-mediated alterations in astrocyte ion transport.

  title={gp120-mediated alterations in astrocyte ion transport.},
  author={Dale J. Benos and Beatrice H. Hahn and George M. Shaw and James K. Bubien and Etty Nadia Benveniste},
  journal={Advances in neuroimmunology},
  volume={4 3},
The pathogenesis of the acquired immunodeficiency syndrome (AIDS) dementia complex (ADC) is unknown. However, recent work indicates that neurons and astrocytes are functionally compromised by exposure to viral components or cellular factors released from HIV-1-infected macrophages/microglia. We show that exposure of primary cultured rat astrocytes to the major HIV envelope glycoprotein gp120 results in alterations of ion and solute transport that may contribute to neuronal cell injury.