gp120-induced neurotoxicity in hippocampal pyramidal neuron cultures: protective action of TGF-beta1.

@article{Meucci1996gp120inducedNI,
  title={gp120-induced neurotoxicity in hippocampal pyramidal neuron cultures: protective action of TGF-beta1.},
  author={Olimpia Meucci and Richard J. Miller},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1996},
  volume={16 13},
  pages={
          4080-8
        }
}
We found that TGF-beta1, a cytokine that previously has been reported to have neuroprotective effects, was able to prevent the toxicity induced by the HIV-1 coat protein gp120 in hippocampal pyramidal neuron cultures. In the presence of glia, gp120 induced time- and dose-dependent cell death, which was more pronounced in mature (7-19 d in culture) than in young neurons (2-7 d in culture). Staining with nuclear dyes (propidium iodide and Hoechst 33342), in situ detection of DNA fragments, and… CONTINUE READING

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