goosecoid expression represses Brachyury in embryonic stem cells and affects craniofacial development in chimeric mice.

@article{Boucher2000goosecoidER,
  title={goosecoid expression represses Brachyury in embryonic stem cells and affects craniofacial development in chimeric mice.},
  author={Diane M Boucher and Mitra Schaeffer and Kirsten Deissler and Catherine A Moore and Joseph D. Gold and Carol A Burdsal and Juanito J. Meneses and Roger A. Pedersen and Mariann Blum},
  journal={The International journal of developmental biology},
  year={2000},
  volume={44 3},
  pages={279-88}
}
The homeobox gene goosecoid, originally identified in Xenopus, is expressed in the organizer or its equivalent during gastrulation in the frog, chick, zebrafish and mouse. To investigate the role of goosecoid in mouse development, we have generated embryonic stem cells that stably overexpress the murine homolog of goosecoid. These cells show a repression of the gastrulation-associated gene Brachyury. Interestingly, repression of Brachyury is conserved between Xenopus and mouse despite the lack… CONTINUE READING
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