• Biology, Medicine
  • Published in Development 1993

glp-1 can substitute for lin-12 in specifying cell fate decisions in Caenorhabditis elegans.

@article{Fitzgerald1993glp1CS,
  title={glp-1 can substitute for lin-12 in specifying cell fate decisions in Caenorhabditis elegans.},
  author={Kevin C Fitzgerald and Hilary A. Wilkinson and Isidor Greenwald},
  journal={Development},
  year={1993},
  volume={119 4},
  pages={
          1019-27
        }
}
Members of the lin-12/Notch gene family encode receptors for intercellular signals and are found throughout the animal kingdom. In many animals, the presence of at least two lin-12/Notch genes raises the issue of the significance of this duplication and divergence. In Caenorhabditis elegans, two lin-12/Notch genes, lin-12 and glp-1, encode proteins that are 50% identical, with different numbers of epidermal growth factor-like motifs in their extracellular domains. Many of the cell fate… CONTINUE READING

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hecd-1 Modulates Notch Activity in Caenorhabditis elegans

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HIGHLY INFLUENCED

Notch signaling: genetics and structure.

  • WormBook : the online review of C. elegans biology
  • 2013
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