gammadelta-T cells expressing NK receptors predominate over NK cells and conventional T cells in the innate IFN-gamma response to Plasmodium falciparum malaria.

@article{DOmbrain2007gammadeltaTCE,
  title={gammadelta-T cells expressing NK receptors predominate over NK cells and conventional T cells in the innate IFN-gamma response to Plasmodium falciparum malaria.},
  author={Marthe C. D'Ombrain and Diana Silvia Hansen and Ken M. Simpson and Louis Schofield},
  journal={European journal of immunology},
  year={2007},
  volume={37 7},
  pages={1864-73}
}
Rapid production of interferon-gamma (IFN-gamma) in response to malaria by the innate immune system may determine resistance to infection, or inflammatory disease. However, conflicting reports exist regarding the identity of IFN-gamma-producing cells that rapidly respond to Plasmodium falciparum. To clarify this area, we undertook detailed phenotyping of IFN-gamma-producing cells across a panel of naive human donors following 24-h exposure to live schizont-infected red blood cells (iRBC). Here… CONTINUE READING