gamma -glutamyltransferase and its isoform mediate an endoplasmic reticulum stress response.

@article{JoyceBrady2001gammaA,
  title={gamma -glutamyltransferase and its isoform mediate an endoplasmic reticulum stress response.},
  author={Martin F Joyce-Brady and Jyh Chang Jean and Rebecca P. Hughey},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 12},
  pages={9468-77}
}
Although use of multiple alternative first exons generates unique noncoding 5'-ends for gamma-glutamyltransferase (GGT) cDNAs in several species, we show here that alternative splicing events also alter coding exons in mouse GGT to produce at least four protein isoforms. GGTDelta1 introduces CAG four bases upstream of the primary ATG codon and encodes an active GGT heterodimeric ectoenzyme identical to constitutive GGT cDNA but translational efficiency is reduced 2-fold. GGTDelta2-5 deletes the… CONTINUE READING