gamma-Protocadherins regulate neuronal survival but are dispensable for circuit formation in retina.

@article{Lefebvre2008gammaProtocadherinsRN,
  title={gamma-Protocadherins regulate neuronal survival but are dispensable for circuit formation in retina.},
  author={Julie L Lefebvre and Yifeng Zhang and Markus Meister and Xiaozhong A. Wang and Joshua R Sanes},
  journal={Development},
  year={2008},
  volume={135 24},
  pages={4141-51}
}
Twenty-two tandemly arranged protocadherin-gamma (Pcdh-gamma) genes encode transmembrane proteins with distinct cadherin-related extracellular domains and a common intracellular domain. Genetic studies have implicated Pcdh-gamma genes in the regulation of neuronal survival and synapse formation. Because mice lacking the Pcdh-gamma cluster die perinatally, we generated conditional mutants to analyze roles of Pcdh-gamma genes in the development and function of neural circuits. Retina-specific… CONTINUE READING

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