gamma-Hydroxybutyrate modulation of glutamate levels in the hippocampus: an in vivo and in vitro study.

@article{Ferraro2001gammaHydroxybutyrateMO,
  title={gamma-Hydroxybutyrate modulation of glutamate levels in the hippocampus: an in vivo and in vitro study.},
  author={Luca Ferraro and Sergio Tanganelli and W. T. O'Connor and W Francesconi and Antonella Loche and Gian Luigi Gessa and Tiziana Antonelli},
  journal={Journal of neurochemistry},
  year={2001},
  volume={78 5},
  pages={929-39}
}
The effect of gamma-hydroxybutyric acid on extracellular glutamate levels in the hippocampus was studied by microdialysis in freely moving rats and in isolated hippocampal synaptosomes. Intra-hippocampal (CA1) perfusion with gamma-hydroxybutyric acid (10 nM-1 mM) concentration-dependently influenced glutamate levels: gamma-hydroxybutyric acid (100 and 500 nM) increased glutamate levels; 100 and 300 microM concentrations were ineffective; whereas the highest 1 mM concentration reduced local… CONTINUE READING