gamma-Glutamyl transpeptidase: catalytic mechanism and gene expression.

@article{Taniguchi1998gammaGlutamylTC,
  title={gamma-Glutamyl transpeptidase: catalytic mechanism and gene expression.},
  author={Naoyuki Taniguchi and Yukio Ikeda},
  journal={Advances in enzymology and related areas of molecular biology},
  year={1998},
  volume={72},
  pages={239-78}
}
The gamma-glutamyl transpeptidases are key enzymes in the so-called gamma-glutamyl cycle involving glutathione synthesis, the recovery of its constituents, and in the transport of amino acids. This membrane-bound ectoenzyme thus serves to regulate glutathione synthesis. This chapter deals with the active site chemistry of gamma-glutamyl transpeptidase, including the role of side-chain groups on the light subunit as well as several serine residues in the catalytic process. Also considered are… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 32 extracted citations

Similar Papers

Loading similar papers…