gamma-Glutamyl transpeptidase: catalytic mechanism and gene expression.

  title={gamma-Glutamyl transpeptidase: catalytic mechanism and gene expression.},
  author={Naoyuki Taniguchi and Yukio Ikeda},
  journal={Advances in enzymology and related areas of molecular biology},
The gamma-glutamyl transpeptidases are key enzymes in the so-called gamma-glutamyl cycle involving glutathione synthesis, the recovery of its constituents, and in the transport of amino acids. This membrane-bound ectoenzyme thus serves to regulate glutathione synthesis. This chapter deals with the active site chemistry of gamma-glutamyl transpeptidase, including the role of side-chain groups on the light subunit as well as several serine residues in the catalytic process. Also considered are… CONTINUE READING

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