gamma-Aminobutyric acidB receptors in the rat brain: quantitative autoradiographic localization using [3H](-)-baclofen.

@article{Gehlert1985gammaAminobutyricAR,
  title={gamma-Aminobutyric acidB receptors in the rat brain: quantitative autoradiographic localization using [3H](-)-baclofen.},
  author={Donald R. Gehlert and Henry I. Yamamura and James K. Wamsley},
  journal={Neuroscience letters},
  year={1985},
  volume={56 2},
  pages={183-8}
}
The light microscopic localization of gamma-aminobutyric acidB (GABAB) receptors in the rat brain has been accomplished using in vitro autoradiography with [3H]baclofen as a ligand. Initial biochemical studies indicated this compound specifically bound to slide-mounted tissue sections with high affinity in a saturable and readily reversible manner. Autoradiograms generated by labeled tissue sections demonstrated high grain densities over structures such as the interpeduncular nucleus, molecular… CONTINUE READING