gamma-Aminobutyric acid stimulates intrinsic inhibitory and excitatory nerves in the guinea-pig intestine.

@article{Krantis1980gammaAminobutyricAS,
  title={gamma-Aminobutyric acid stimulates intrinsic inhibitory and excitatory nerves in the guinea-pig intestine.},
  author={Anthony Krantis and Marcello Costa and John Barton Furness and Joseph Orbach},
  journal={European journal of pharmacology},
  year={1980},
  volume={67 4},
  pages={461-8}
}
The sites of action of gamma-aminobutyric acid (GABA) were examined in preparations of the distal colon and ileum of guinea pigs. GABA caused transient relaxations of the longitudinal and circular muscle of the colon and transient contractions followed by relaxation of the muscle of the ileum. The responses of both parts of the intestine were antagonized by tetrodotoxin and by bicuculline. Nerve-free preparations of the longitudinal muscle of the ileum were not affected by GABA, even in… CONTINUE READING

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