gamma-Aminobutyric acid-B receptors inhibit glutamate release from cerebellar granule cells: consequences of inhibiting cyclic AMP formation and calcium influx.

@article{Travagli1991gammaAminobutyricAR,
  title={gamma-Aminobutyric acid-B receptors inhibit glutamate release from cerebellar granule cells: consequences of inhibiting cyclic AMP formation and calcium influx.},
  author={R Alberto Travagli and M Ulivi and Wadyslaw Wojcik},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1991},
  volume={258 3},
  pages={903-9}
}
In cerebellar granule cells, baclofen acted with micromolar concentrations at proposed gamma-aminobutyric acid-B receptors to inhibit the formation of cyclic AMP and depolarization-induced release of glutamate. Nanomolar concentrations of baclofen inhibited depolarization-induced influx of calcium. All three responses to baclofen were attenuated after pertussis toxin pretreatment of cell cultures. The inhibition of calcium influx and glutamate release were reversed by the cyclic AMP analog, 8… CONTINUE READING