gamma-Aminobutyric acid (GABA) metabolism in mammalian neural and nonneural tissues.

  title={gamma-Aminobutyric acid (GABA) metabolism in mammalian neural and nonneural tissues.},
  author={Niranjala J. K. Tillakaratne and Lali K. Medina-Kauwe and K Michael Gibson},
  journal={Comparative biochemistry and physiology. Part A, Physiology},
  volume={112 2},
4-Aminobutyric acid (GABA), a major inhibitory neurotransmitter of mammalian central nervous system, is found in a wide range of organisms, from prokaryotes to vertebrates. GABA is widely distributed in nonneural tissue including peripheral nervous and endocrine systems. GABA acts on GABAA and GABAB receptors. GABAA receptors are ligand-gated chloride channels modulated by a variety of drugs. GABAB receptors are essentially presynaptic, usually coupled to potassium or calcium channels, and they… CONTINUE READING


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