gamma-Aminobutyric acid (GABA) induces a receptor-mediated reduction in GABAA receptor alpha subunit messenger RNAs in embryonic chick neurons in culture.

@article{Montpied1991gammaAminobutyricA,
  title={gamma-Aminobutyric acid (GABA) induces a receptor-mediated reduction in GABAA receptor alpha subunit messenger RNAs in embryonic chick neurons in culture.},
  author={Pascale Montpied and EdwardI. Ginns and Brian M. Martin and Dom{\'i}nguez Roca and David H. Farb and Steven M Paul},
  journal={The Journal of biological chemistry},
  year={1991},
  volume={266 10},
  pages={
          6011-4
        }
}
gamma-Aminobutyric acid (GABA), the major inhibitory neurotransmitter in brain, is known to interact with a subclass of receptors that activate a ligand-gated chloride ion channel. Exposure of cultured embryonic chick neurons to physiological concentrations of GABA results in a time-dependent down-regulation of these GABAA receptors. To delineate the cellular mechanism(s) responsible for agonist-induced down-regulation of GABAA receptors we quantified the levels of GABAA receptor alpha subunit… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 13 CITATIONS

Plasticity of central autonomic neural circuits in diabetes.

  • Biochimica et biophysica acta
  • 2009
VIEW 1 EXCERPT
CITES BACKGROUND

A developmental shift from GABAergic to glycinergic transmission in the central auditory system.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1998
VIEW 1 EXCERPT
CITES BACKGROUND

Similar Papers