gCap39, a calcium ion- and polyphosphoinositide-regulated actin capping protein.

@article{Yu1990gCap39AC,
  title={gCap39, a calcium ion- and polyphosphoinositide-regulated actin capping protein.},
  author={Fu-Shin X Yu and Patricia A. Johnston and Thomas C S{\"u}dhof and Helen L. Yin},
  journal={Science},
  year={1990},
  volume={250 4986},
  pages={1413-5}
}
The polymerization of actin filaments is involved in growth, movement, and cell division. It has been shown that actin polymerization is controlled by gelsolin, whose interactions with actin are activated by calcium ion (Ca2+) and inhibited by membrane polyphosphoinositides (PPI). A smaller Ca2(+)- and PPI-regulated protein, gCap39, which has 49% sequence identity with gelsolin, has been identified by cDNA cloning and protein purification. Like gelsolin, gCap39 binds to the fast-growing (+) end… CONTINUE READING