gC1qR/p33 serves as a molecular bridge between the complement and contact activation systems and is an important catalyst in inflammation.

@article{Ghebrehiwet2006gC1qRp33SA,
  title={gC1qR/p33 serves as a molecular bridge between the complement and contact activation systems and is an important catalyst in inflammation.},
  author={Berhane Ghebrehiwet and Claudia CebadaMora and Lee Tantral and Jolyon Jesty and Ellinor I. B. Peerschke},
  journal={Advances in experimental medicine and biology},
  year={2006},
  volume={586},
  pages={95-105}
}
The receptor for the globular heads of C1q, gC1qR/p33, is a ubiquitously expressed protein, which is distributed both intracellularly and on the cell-surface protein. In addition to C1q, this molecule also is able to bind several other biologically important plasma ligands, including high-molecular-weight kininogen (HK), factor XII (FXII), and multimeric vitronectin. Previous studies have shown that incubation of FXII, prekallikrein, and HK with gC1qR leads to a zinc-dependent and FXII… CONTINUE READING

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