• Corpus ID: 27758279

fficacy and Safety of Transcranial Magnetic timulation in the Acute Treatment of Major epression : A Multisite Randomized Controlled Trial

@inproceedings{OReardon2007fficacyAS,
  title={fficacy and Safety of Transcranial Magnetic timulation in the Acute Treatment of Major epression : A Multisite Randomized Controlled Trial},
  author={ohn P. O’Reardon and Hugh Brent Solvason and Philip G. Janicak and Shirlene M. Sampson and Keith E. Isenberg and iad Nahas and William M. McDonald and David H Avery and Paul B. Fitzgerald and Colleen K. Loo and Mark A Demitrack and Shefin Sam George and Harold A. Sackeim},
  year={2007}
}
ethods: In a double-blind, multisite study, 301 medication-free patients with major depression who had not benefited from prior reatment were randomized to active (n 155) or sham TMS (n 146) conditions. Sessions were conducted five times per week with TMS t 10 pulses/sec, 120% of motor threshold, 3000 pulses/session, for 4 – 6 weeks. Primary outcome was the symptom score change as assessed t week 4 with the Montgomery–Asberg Depression Rating Scale (MADRS). Secondary outcomes included changes… 

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