ffi cacy of the platelet glycoprotein Ib antagonist an fi batide in murine models of thrombotic thrombocytopenic purpura

@inproceedings{Zheng2016ffiCO,
  title={ffi cacy of the platelet glycoprotein Ib antagonist an fi batide in murine models of thrombotic thrombocytopenic purpura},
  author={Liang Rong Zheng and Y Mao and Mohammad S. Abdelgawwad and Nicole K. Kocher and Mandy Li and Xiangrong Dai and Benjamin Xiaoyi Li and Xinglong Zheng},
  year={2016}
}
• Anfibatide potently inhibits platelet agglutination under static and arterial shear conditions. • Anfibatide is efficacious in treating spontaneous or shigatoxin-induced murine models of thrombotic thrombocytopenic purpura. Thrombotic thrombocytopenic purpura (TTP), a potentially fatal blood clot disorder, is primarily caused by severe deficiency of plasma ADAMTS13 activity resulting from acquired autoantibodies. Plasma exchange is the only effective initial therapy. However, the high… CONTINUE READING

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