There are reported changes in the indices of the immunoreactivity of the body in employees in modern productions of sulphate cellulose in dependence on the specificity of exposing factors of the production environment. At that the main adverse factor affecting the state of the immune reactivity of workers was found to be is air pollution of the working area with methyl-sulfur compounds in the pulping process, with chlorine and chlorine dioxide--in the process of bleaching, lime and limestone dust--in the process of caustic regeneration. There were shown differences in the character and severity of the immune response to the impact of different chemical compounds. The exertion of protective immune mechanisms is most pronounced in workers employed in the process of boiling and bleaching, in whom there were revealed significant changes in humoral compartment of immunity (pronounced inhibition of the IgA synthesis, which plays an important role in the state of broncho-pulmonary immunity). At the same time, the inhibition of the functional activity of phagocytic neutrophils was the most significant in workers who was experienced to the exposure to lime and limestone dust, testifying about the depression of nonspecific mechanisms of anti-infectious protection. The revealed changes in the immune system are the basis for the formation in workers certain health disorders, mainly with broncho-pulmonary pathology.