feG-COOH blunts eosinophilic airway inflammation in a feline model of allergic asthma

  title={feG-COOH blunts eosinophilic airway inflammation in a feline model of allergic asthma},
  author={A. DeClue and E. Schooley and Laura A. Nafe and C. Reinero},
  journal={Inflammation Research},
Objective and designThis study investigated if feG-COOH would decrease allergen-induced airway inflammation.Materials or subjectsSeven adult cats sensitised to Bermuda grass allergen (BGA) to induce an asthmatic phenotype.TreatmentCats were randomized to receive either feG-COOH (1 mg/kg, PO) or placebo (saline 1 ml, PO) immediately prior to BGA aerosol challenge in a cross-over design.MethodsBronchoalveolar lavage fluid (BALF) was collected and airway inflammatory response assessed via… Expand
12 Citations
Chronic use of the immunomodulating tripeptide feG-COOH in experimental feline asthma.
  • 16
[Feline asthma and chronic bronchitis - an overview of diagnostics and therapy].
  • 1
Advances in the understanding of pathogenesis, and diagnostics and therapeutics for feline allergic asthma.
  • 58
Feline Asthma: What's New and where might Clinical Practice be Heading?
  • 22
Animal models of asthma: utility and limitations
  • 64
  • PDF
Calcium-binding protein, spermatid-specific 1 is expressed in human salivary glands and contains an anti-inflammatory motif.
  • 4
  • PDF
Immunomodulators in feline asthma
  • Highly Influenced
  • PDF


Frontline: Inhibition of allergen‐induced pulmonary inflammation by the tripeptide feG: a mimetic of a neuro‐endocrine pathway
  • 36
Nitric oxide metabolites in induced sputum: a noninvasive marker of airway inflammation in asthma.
  • 13
  • PDF
Persistent airway hyperresponsiveness and histologic alterations after chronic antigen challenge in cats.
  • 179
The use of exhaled nitric oxide to guide asthma management: a randomized controlled trial.
  • 327
  • PDF
Role of nitric oxide on eosinophilic lung inflammation in allergic mice.
  • L. Feder, D. Stelts, +9 authors T. Kung
  • Chemistry, Medicine
  • American journal of respiratory cell and molecular biology
  • 1997
  • 100
  • PDF
Marked antiinflammatory effects of decentralization of the superior cervical ganglia
  • 44
  • PDF
Feline asthma syndrome: a retrospective study of the clinical presentation in 29 cats.
  • 93
An Experimental Model of Allergic Asthma in Cats Sensitized to House Dust Mite or Bermuda Grass Allergen
  • 91
  • Highly Influential
Characterization of T Cell Subpopulations Involved in the Pathogenesis of Asthma and Allergic Diseases
  • 112