fast1 is required for the development of dorsal axial structures in zebrafish

@article{Sirotkin2000fast1IR,
  title={fast1 is required for the development of dorsal axial structures in zebrafish},
  author={Howard I Sirotkin and Michael A. Gates and Peter D. Kelly and Alexander F Schier and William S. Talbot},
  journal={Current Biology},
  year={2000},
  volume={11}
}
Nodal-related signals comprise a subclass of the transforming growth factor-beta (TGF-beta) superfamily and regulate key events in vertebrate embryogenesis, including mesoderm formation, establishment of left-right asymmetry and neural patterning [1-8]. Nodal ligands are thought to act with EGF-CFC protein co-factors to activate activin type I and II or related receptors, which phosphorylate Smad2 and trigger nuclear translocation of a Smad2/4 complex [8-12]. The winged-helix transcription… CONTINUE READING