fMRI of Cocaine Self-Administration in Macaques Reveals Functional Inhibition of Basal Ganglia

@article{Mandeville2011fMRIOC,
  title={fMRI of Cocaine Self-Administration in Macaques Reveals Functional Inhibition of Basal Ganglia},
  author={Joseph B. Mandeville and Ji-Kyung Choi and B{\'e}chir Jarraya and Bruce R. Rosen and Bruce G. Jenkins and Wim Vanduffel},
  journal={Neuropsychopharmacology},
  year={2011},
  volume={36},
  pages={1187-1198}
}
Disparities in cocaine-induced neurochemical and metabolic responses between human beings and rodents motivate the use of non-human primates (NHP) to model consequences of repeated cocaine exposure in human subjects. To characterize the functional response to cocaine infusion in NHP brain, we employed contrast-enhanced fMRI during both non-contingent injection of drug and self-administration of cocaine in the magnet. Cocaine robustly decreased cerebral blood volume (CBV) throughout basal… CONTINUE READING

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