eview of Trabectedin ( ET-743 ) : A Unique Ther hanism of Action zio

@inproceedings{DIncalci2010eviewOT,
  title={eview of Trabectedin ( ET-743 ) : A Unique Ther hanism of Action zio},
  author={D'Incalci and Carlos M Galmarini},
  year={2010}
}
ownload ectedin (ET-743) is a marine alkaloid isolated from the Caribbean tunicate Ecteinascidia turbinata, with ical structure characterized by three fused tetrahydroisoquinoline rings. Two of these rings (subunits B) provide the framework for covalent interaction with the minor groove of the DNA double helix, as the third ring (subunit C) protrudes from the DNA duplex, apparently allowing interactions with nt nuclear proteins. The compound's chemical interactions trigger a cascade of events… CONTINUE READING