ereditary Elliptocytosis : Spectrin and Protein 4 . 1 R


ereditary elliptocytosis (HE) is a common disorder of erythrocyte shape, occurring especially in individuals of African nd Mediterranean ancestry, presumably because elliptocytes confer some resistance to malaria. The principle lesion n HE is mechanical weakness or fragility of the erythrocyte membrane skeleton due to defects in -spectrin, -spectrin, r… (More)

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