erbB3 is an active tyrosine kinase capable of homo- and heterointeractions.

  title={erbB3 is an active tyrosine kinase capable of homo- and heterointeractions.},
  author={Mara P. Steinkamp and Shalini T. Low-Nam and Shujie Yang and Keith A. Lidke and Diane S. Lidke and Bridget S. Wilson},
  journal={Molecular and cellular biology},
  volume={34 6},
Often considered to be a "dead" kinase, erbB3 is implicated in escape from erbB-targeted cancer therapies. Here, heregulin stimulation is shown to markedly upregulate kinase activity in erbB3 immunoprecipitates. Intact, activated erbB3 phosphorylates tyrosine sites in an exogenous peptide substrate, and this activity is abolished by mutagenesis of lysine 723 in the catalytic domain. Enhanced erbB3 kinase activity is linked to heterointeractions with catalytically active erbB2, since it is… CONTINUE READING

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