erbB-2 overexpression in human mammary epithelial cells confers growth factor independence.

@article{Ignatoski1999erbB2OI,
  title={erbB-2 overexpression in human mammary epithelial cells confers growth factor independence.},
  author={Kathleen M. Woods Ignatoski and Adrien Lapointe and Eric H. Radany and Stephen P Ethier},
  journal={Endocrinology},
  year={1999},
  volume={140 8},
  pages={3615-22}
}
Previously, we demonstrated that human breast cancer cells with progressively elevated levels of constitutively tyrosine phosphorylated erbB-2 are independent of growth factors required by normal human mammary epithelial (HME) cells for proliferation in serum-free medium. To determine whether erbB-2 overexpression alone is sufficient to confer the growth… CONTINUE READING