erbB-2/neu transformed rat cholangiocytes recapitulate key cellular and molecular features of human bile duct cancer.

@article{Lai2005erbB2neuTR,
  title={erbB-2/neu transformed rat cholangiocytes recapitulate key cellular and molecular features of human bile duct cancer.},
  author={G H Lai and Zichen Zhang and Xue-Ning Shen and Deanna J Ward and Jennifer L Dewitt and Shawn E. Holt and Rebecca A Rozich and Douglas C. Hixson and Alphonse E. Sirica},
  journal={Gastroenterology},
  year={2005},
  volume={129 6},
  pages={2047-57}
}
BACKGROUND & AIMS Cholangiocarcinomas appear to arise from the malignant transformation of cholangiocytes lining the biliary tract. Because the development of an in vitro model of malignant transformation can provide a powerful new tool for establishing critical events governing the molecular pathogenesis of cholangiocarcinoma, we investigated the potential of achieving malignant transformation of cultured rat cholangiocytes in relation to aberrant overexpression of mutationally activated erbB… CONTINUE READING

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