eps15 and eps15R are essential components of the endocytic pathway.

  title={eps15 and eps15R are essential components of the endocytic pathway.},
  author={Roberta Carbone and Silvia Fre and Gioacchin Iannolo and Francesca Belleudi and Patrizia Mancini and Pier Giuseppe Pelicci and Maria Rosaria Torrisi and Pier Paolo Di Fiore},
  journal={Cancer research},
  volume={57 24},
eps15 and eps1SR are substrates of the epidermal growth factor (EGF) receptor kinase that are characterized by the presence of a protein:protein interaction domain, the EH domain, and by their ability to bind to the clathrin adaptor protein complex adaptor protein 2. Indirect evidence suggests that eps15 and eps15R are involved in endocytosis. Here we show that microinjection of antibodies against eps15 and eps15R inhibits internalization of EGF and transferrin. In addition, fragments of eps15… CONTINUE READING