egenerative Endodontics: A Review of Current Status nd a Call for Action


d c a t u n a b a g bstract illions of teeth are saved each year by root canal therpy. Although current treatment modalities offer high evels of success for many conditions, an ideal form of herapy might consist of regenerative approaches in which iseased or necrotic pulp tissues are removed and relaced with healthy pulp tissue to revitalize teeth. Reearchers are working toward this objective. Regenerative ndodontics is the creation and delivery of tissues to eplace diseased, missing, and traumatized pulp. This reiew provides an overview of regenerative endodontics nd its goals, and describes possible techniques that will llow regenerative endodontics to become a reality. These otential approaches include root-canal revascularization, ostnatal (adult) stem cell therapy, pulp implant, scaffold mplant, three-dimensional cell printing, injectable scafolds, and gene therapy. These regenerative endodontic echniques will possibly involve some combination of disnfection or debridement of infected root canal systems ith apical enlargement to permit revascularization and se of adult stem cells, scaffolds, and growth factors. lthough the challenges of introducing endodontic tissue ngineering therapies are substantial, the potential beneits to patients and the profession are equally ground reaking. Patient demand is staggering both in scope and ost, because tissue engineering therapy offers the possiility of restoring natural function instead of surgical lacement of an artificial prosthesis. By providing an overiew of the methodological issues required to develop otential regenerative endodontic therapies, we hope to resent a call for action to develop these therapies for linical use. (J Endod 2007;33:377–390)

Cite this paper

@inproceedings{Murray2007egenerativeEA, title={egenerative Endodontics: A Review of Current Status nd a Call for Action}, author={Ellen Murray and Hons and Franklin Garcia - Godoy and enneth M . Hargreaves}, year={2007} }