eRNAs are required for p53-dependent enhancer activity and gene transcription.

  title={eRNAs are required for p53-dependent enhancer activity and gene transcription.},
  author={Carlos Andr{\'e} Ara{\'u}jo Melo and Jarno Drost and Patrick J E C Wijchers and Harmen J G van de Werken and Elzo de Wit and Joachim A F Oude Vrielink and Ran Elkon and S{\'o}nia A. Melo and Nicolas L{\'e}veill{\'e} and Raghu Kalluri and Wouter de Laat and Reuven Agami},
  journal={Molecular cell},
  volume={49 3},
Binding within or nearby target genes involved in cell proliferation and survival enables the p53 tumor suppressor gene to regulate their transcription and cell-cycle progression. Using genome-wide chromatin-binding profiles, we describe binding of p53 also to regions located distantly from any known p53 target gene. Interestingly, many of these regions possess conserved p53-binding sites and all known hallmarks of enhancer regions. We demonstrate that these p53-bound enhancer regions (p53BERs… CONTINUE READING
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