eNOS overexpression exacerbates vascular closure in the obliterative phase of OIR and increases angiogenic drive in the subsequent proliferative stage.

@article{Edgar2012eNOSOE,
  title={eNOS overexpression exacerbates vascular closure in the obliterative phase of OIR and increases angiogenic drive in the subsequent proliferative stage.},
  author={Kevin S. Edgar and Thomas A. Gardiner and Rien van Haperen and Rini de Crom and Denise McDonald},
  journal={Investigative ophthalmology & visual science},
  year={2012},
  volume={53 11},
  pages={6833-50}
}
PURPOSE In ischemic retinopathies, the misdirection of reparative angiogenesis away from the hypoxic retina leads to pathologic neovascularization. Thus, therapeutic strategies that reverse this trend would be extremely beneficial. Nitric oxide (NO) produced by endothelial nitric oxide synthase (eNOS) is an important mediator of vascular endothelial growth… CONTINUE READING