eNOS function is developmentally regulated: uncoupling of eNOS occurs postnatally.

@article{MataGreenwood2006eNOSFI,
  title={eNOS function is developmentally regulated: uncoupling of eNOS occurs postnatally.},
  author={Eugenia Mata-Greenwood and Chrystal Jenkins and Kathryn N Farrow and Girija Ganesh Konduri and James A Russell and Satyan Lakshminrusimha and S. M. Black and Robin Heise Steinhorn},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2006},
  volume={290 2},
  pages={L232-41}
}
At birth, the transition to gas breathing requires the function of endothelial vasoactive agents. We investigated the function of endothelial nitric oxide synthase (eNOS) in pulmonary artery (PA) vessels and endothelial cells isolated from fetal and young (4-wk) sheep. We found greater relaxations to the NOS activator A-23187 in 4-wk-old compared with fetal vessels and that the NOS inhibitor nitro-L-arginine blocked relaxations in both groups. Relaxations in 4-wk vessels were not blocked by an… CONTINUE READING

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Developmental differences in endothelium-dependent responses in iso L240 DEVELOPMENTAL REGULATION OF ENOS AJP-Lung Cell Mol Physiol

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