eNOS activity is reduced in senescent human endothelial cells: Preservation by hTERT immortalization.

@article{Matsushita2001eNOSAI,
  title={eNOS activity is reduced in senescent human endothelial cells: Preservation by hTERT immortalization.},
  author={Hidetsugu Matsushita and Edward K. Chang and Alexander J Glassford and John P Cooke and C P Chiu and Philip S. Tsao},
  journal={Circulation research},
  year={2001},
  volume={89 9},
  pages={793-8}
}
Advanced age is associated with endothelial dysfunction and increased risk for atherosclerosis. However, the mechanisms for these observed effects are not clear. To clarify the association between aging and loss of endothelial function, young human aortic endothelial cells (HAECs), senescent HAECs transfected with control vector, and immortalized HAECs containing human telomerase reverse transcriptase (hTERT) were compared for expression of endothelial nitric oxide synthase (eNOS) and… CONTINUE READING
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