eNOS [Glu298Asp] polymorphism, erectile function and ocular pressure in type 2 diabetes

  title={eNOS [Glu298Asp] polymorphism, erectile function and ocular pressure in type 2 diabetes},
  author={Michel P. Hermans and Sylvie A. Ahn and Michel F. Rousseau},
  journal={European Journal of Clinical Investigation},
Eur J Clin Invest 2012; 42 (7): 729–737 

The association of Intron 4 VNTR and Glu298Asp polymorphisms of the nitric oxide synthetase 3 gene and vasculogenic erectile dysfunction in Turkish men

In contrast to Glu298Asp, statistically significant differences in genotypic frequencies of Intron 4 VNTR gene polymorphism between ED and control subjects was established.

Diabetes mellitus and late‐onset hypogonadism: the role of Glu298Asp endothelial nitric oxide synthase polymorphism

It is suggested that Glu298Asp single nucleotide polymorphism of the eNOS gene may be an independent risk factor for hypogonadism‐associated type 2 DM.

The association of T786C and G894T polymorphisms of eNOS gene with diabetic retinopathy in Greece

It is documented that rs1799983 GT genotype could be recognized as an independent risk factor of retinopathy in Greek patients with type-2 diabetes mellitus, while no role for rs2070744 polymorphism was identified.

Polymorphic variations in manganese superoxide dismutase (MnSOD) and endothelial nitric oxide synthase (eNOS) genes contribute to the development of type 2 diabetes mellitus in the Chinese Han population.

The results indicate that common variants in MnSOD and eNOS increased the risk of T2DM in the Chinese Han population.

Association of endothelial nitric oxide synthase gene G894T polymorphism and serum nitric oxide levels in patients with preeclampsia and gestational hypertension*

  • M. SakarA. Atay F. Verit
  • Medicine, Biology
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2015
A relation between pregnancy-induced hypertension and low NO levels is established and an association between eNOS gene G894T polymorphism and serum NO levels in patients with pregnancy- induced hypertensive disorders is established.

Endothelial Nitric Oxide Synthase (eNOS) as a Therapeutic Target in Type 2 Diabetes Mellitus and Its Vascular Complications: A Narrative Review

Modulation of NO in interventions indirectly or directly have modulated NO relayed to its work targets such as oral antidiabetic drugs or some polyphenol compounds can be strong evidence that NO can be a target for further therapy in the management of T2DM and its complications.



Association of the T‐786C, G894T and 4a/4b polymorphisms of the endothelial nitric oxide synthase gene with vasculogenic erectile dysfunction in Iranian subjects

The largest ever study of its kind has been conducted on the role of language and culture in the development of Alzheimer's disease and its effects on physical and mental health.

Glu298Asp endothelial nitric oxide synthase polymorphism is a risk factor for erectile dysfunction in the Mexican Mestizo population.

The results suggest that Glu298Asp eNOS polymorphism plays a role as a genetic susceptibility factor for erectile dysfunction.

The functional consequence of the Glu298Asp polymorphism of the endothelial nitric oxide synthase gene in young healthy volunteers.

The data show that carriage of the Asp298 variant of the eNOS gene is associated with a blunted endothelial-dependent vasodilation in healthy volunteers, supporting a genetically determined modulation of endothelial dysfunction, a phenotype of early atherosclerosis in humans.

Gene-polymorphisms of angiotensin converting enzyme and endothelial nitric oxide synthase in patients with erectile dysfunction

The deletion polymorphism in the ACE gene, the DD genotype, as a marker of general vascular disease, may be seen more frequently in men with a diagnosis of vasculogenic erectile dysfunction.

Association analysis of endothelial nitric oxide synthase G894T gene polymorphism and erectile dysfunction complaints in a population-based survey.

The results do not support a major role for eNOS gene polymorphisms in ED in this population of men, and univariate analysis demonstrated that ED was associated with diabetes, hypertension, sleep apnea severity, increasing age and body mass index, as well as testosterone levels.

Functional gene testing of the Glu298Asp polymorphism of the endothelial NO synthase

The functional genetic study does not suggest any biological effect of the eNOS Glu298Asp genotype on the cardiovascular system via an influence on endothelium-dependent vasodilation.

Endothelial Nitric Oxide Gene Haplotypes and Risk of Cerebral Small-Vessel Disease

It is suggested that the protective effect of the 4a variant could be mediated through changes in eNOS promoter activity and increased NO levels, and may reflect different etiopathogeneses of the 2 subtypes.