eLCR: electrochemical detection of single DNA base changes via ligase chain reaction.

Abstract

Simple, inexpensive and wide-scaled analysis of single DNA base changes ('point mutations' which include SNP's, somatic mutations and epigenetic changes) is one of the holy grail's of point-of-care diagnostics. Herein, we present eLCR: a simple methodology that fuses Ligase Chain Reaction (LCR) with electrochemical detection based on DNA-mediated charge… (More)
DOI: 10.1039/c2cc35841g

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