eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription

  title={eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription},
  author={Daniela Brina and Annarita Miluzio and Sara Ricciardi and Kim Clarke and Peter K. Davidsen and Gabriella Viero and Toma Tebaldi and Nina Offenh{\"a}user and Jan Rozman and Birgit Rathkolb and Susanne Neschen and Martin Klingenspor and Eckhard Wolf and Val{\'e}rie Gailus-Durner and Helmut Fuchs and Martin Hrabě de Angelis and Alessandro Quattrone and Francesco Falciani and Stefano Biffo},
  booktitle={Nature communications},
Insulin regulates glycaemia, lipogenesis and increases mRNA translation. Cells with reduced eukaryotic initiation factor 6 (eIF6) do not increase translation in response to insulin. The role of insulin-regulated translation is unknown. Here we show that reduction of insulin-regulated translation in mice heterozygous for eIF6 results in normal glycaemia, but less blood cholesterol and triglycerides. eIF6 controls fatty acid synthesis and glycolysis in a cell autonomous fashion. eIF6 acts by… CONTINUE READING
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Proceedings of the National Academy of Sciences of the United States of America • 2017
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