eIF5A binds to translational machinery components and affects translation in yeast.

@article{Zanelli2006eIF5ABT,
  title={eIF5A binds to translational machinery components and affects translation in yeast.},
  author={Cleslei Fernando Zanelli and Ana Leticia G C Maragno and Ana Paula Borges Gregio and Suzanne Komili and Jos{\'e} Rodrigo Cl{\'a}udio Pandolfi and Carlos Alberto Mestriner and W R Lustri and Sandro Roberto Valentini},
  journal={Biochemical and biophysical research communications},
  year={2006},
  volume={348 4},
  pages={1358-66}
}
The putative translation factor eIF5A is essential for cell viability and is highly conserved from archebacteria to mammals. Although this protein was originally identified as a translation initiation factor, subsequent experiments did not support a role for eIF5A in general translation. In this work, we demonstrate that eIF-5A interacts with structural components of the 80S ribosome, as well as with the translation elongation factor 2 (eEF2). Moreover, eIF5A is further shown to cofractionate… CONTINUE READING

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