eIF5A and EF-P: two unique translation factors are now traveling the same road.

Danuza Rossi, Reginaldo Kuroshu, Cleslei Fernando Zanelli, Sandro Roberto Valentini
Published 2014 in Wiley interdisciplinary reviews. RNA

Abstract

Translational control is extremely important in all organisms, and some of its aspects are highly conserved among all primary kingdoms, such as those related to the translation elongation step. The previously classified translation initiation factor 5A (eIF5A) and its bacterial homologue elongation factor P (EF-P) were discovered in the late 70's and have… (More)

DOI: 10.1002/wrna.1211

SI Chung, MH Park, JE Folk, MS. Lewis
Biochim Biophys Acta
2014

eIF5A and EF-P: two unique translation factors are now traveling the same road.

Abstract

Topics

5 Figures and Tables

Cited By

KRAS Oncoprotein Expression Is Regulated by a Self-Governing eIF5A-PEAK1 Feed-Forward Regulatory Loop.

The translation factor eIF5A and human cancer.

A new non-radioactive deoxyhypusine synthase assay adaptable to high throughput screening

Essential structural elements in tRNAPro for EF-P-mediated alleviation of translation stalling

Evidence for a Negative Cooperativity between eIF5A and eEF2 on Binding to the Ribosome

Global quantitative proteomics reveal up-regulation of endoplasmic reticulum stress response proteins upon depletion of eIF5A in HeLa cells.

Mapping surface residues of eIF5A that are important for binding to the ribosome using alanine scanning mutagenesis

Overexpression of EIF5A2 correlates with tumor progression and predicts poor prognosis in cervical cancer

Analysis of gene expression of bifidobacteria using as the reporter an anaerobic fluorescent protein

Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi

References

Eukaryotic initiation factor 5A: the molecular form of the Volume 5, March/Apr i l 2014

Hypusine modification of the ribosome-binding protein eIF5A, a target for new anti-inflammatory drugs: understanding the action of the inhibitor GC7 on a murine macrophage cell line.

(R)-β-lysine-modified elongation factor P functions in translation elongation.

An in vivo control map for the eukaryotic mRNA translation machinery

Divergent Protein Motifs Direct Elongation Factor P-Mediated Translational Regulation in Salmonella enterica and Escherichia coli

EF-P is essential for rapid synthesis of proteins containing consecutive proline residues.

Elongation Factor P is Dispensable in Escherichia coli and Pseudomonas aeruginosa

Eukaryotic initiation factor 5A dephosphorylation is required for translational arrest in stationary phase cells.

Nascent peptides that block protein synthesis in bacteria.

Role of p38 and JNK MAPK signaling pathways and tumor suppressor p53 on induction of apoptosis in response to Ad-eIF5A1 in A549 lung cancer cells

Slides referencing similar topics

eIF5A and EF-P: two unique translation factors are now traveling the same road.

Abstract

Topics

5 Figures and Tables

Cited By

KRAS Oncoprotein Expression Is Regulated by a Self-Governing eIF5A-PEAK1 Feed-Forward Regulatory Loop.

The translation factor eIF5A and human cancer.

A new non-radioactive deoxyhypusine synthase assay adaptable to high throughput screening

Essential structural elements in tRNAPro for EF-P-mediated alleviation of translation stalling

Evidence for a Negative Cooperativity between eIF5A and eEF2 on Binding to the Ribosome

Global quantitative proteomics reveal up-regulation of endoplasmic reticulum stress response proteins upon depletion of eIF5A in HeLa cells.

Mapping surface residues of eIF5A that are important for binding to the ribosome using alanine scanning mutagenesis

Overexpression of EIF5A2 correlates with tumor progression and predicts poor prognosis in cervical cancer

Analysis of gene expression of bifidobacteria using as the reporter an anaerobic fluorescent protein

Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi

References

Eukaryotic initiation factor 5A: the molecular form of the Volume 5, March/Apr i l 2014

Hypusine modification of the ribosome-binding protein eIF5A, a target for new anti-inflammatory drugs: understanding the action of the inhibitor GC7 on a murine macrophage cell line.

(R)-β-lysine-modified elongation factor P functions in translation elongation.

An in vivo control map for the eukaryotic mRNA translation machinery

Divergent Protein Motifs Direct Elongation Factor P-Mediated Translational Regulation in Salmonella enterica and Escherichia coli

EF-P is essential for rapid synthesis of proteins containing consecutive proline residues.

Elongation Factor P is Dispensable in Escherichia coli and Pseudomonas aeruginosa

Eukaryotic initiation factor 5A dephosphorylation is required for translational arrest in stationary phase cells.

Nascent peptides that block protein synthesis in bacteria.

Role of p38 and JNK MAPK signaling pathways and tumor suppressor p53 on induction of apoptosis in response to Ad-eIF5A1 in A549 lung cancer cells

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