eIF4E threshold levels differ in governing normal and neoplastic expansion of mammary stem and luminal progenitor cells.

@article{Avdulov2015eIF4ETL,
  title={eIF4E threshold levels differ in governing normal and neoplastic expansion of mammary stem and luminal progenitor cells.},
  author={Svetlana V. Avdulov and Jeremy Herrera and Karen Y. Smith and Mark Peterson and Jose R Gomez-Garcia and Thomas C. Beadnell and Kathryn L Schwertfeger and Alexey O Benyumov and Juan Carlos Manivel and Shunan Li and Anja-Katrin Bielinsky and Douglas Yee and Peter B Bitterman and Vitaly A. Polunovsky},
  journal={Cancer research},
  year={2015},
  volume={75 4},
  pages={687-97}
}
Translation initiation factor eIF4E mediates normal cell proliferation, yet induces tumorigenesis when overexpressed. The mechanisms by which eIF4E directs such distinct biologic outputs remain unknown. We found that mouse mammary morphogenesis during pregnancy and lactation is accompanied by increased cap-binding capability of eIF4E and activation of the eIF4E-dependent translational apparatus, but only subtle oscillations in eIF4E abundance. Using a transgenic mouse model engineered so that… CONTINUE READING
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