eIF4E is an adverse prognostic marker of melanoma patient survival by increasing melanoma cell invasion.

@article{Khosravi2015eIF4EIA,
  title={eIF4E is an adverse prognostic marker of melanoma patient survival by increasing melanoma cell invasion.},
  author={S. B. Abbas Khosravi and Kevin J. Tam and Gholamreza Safaee Ardekani and Magdalena Martinka and Kevin J McElwee and Christopher J Ong},
  journal={The Journal of investigative dermatology},
  year={2015},
  volume={135 5},
  pages={1358-1367}
}
Human cutaneous melanoma is a devastating skin cancer because of its invasive nature and high metastatic potential. We used tissue microarray to study the role of human eukaryotic translation initiation factor 4E (eIF4E) in melanoma progression in 448 melanocytic lesions and found that high eIF4E expression was significantly increased in primary melanomas compared with dysplastic nevi (P<0.001), and further increased in metastatic melanomas (P<0.001). High eIF4E expression was associated with… CONTINUE READING
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