eIF4E Resistance: Natural Variation Should Guide Gene Editing.


eIF4E translation initiation factors have emerged as major susceptibility factors for RNA viruses. Natural eIF4E-based resistance alleles are found in many species and are mostly variants that maintain the translation function of the protein. eIF4E genes represent major targets for engineering viral resistance, and gene-editing technologies can be used to… (More)
DOI: 10.1016/j.tplants.2017.01.008


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