eIF4E – from translation to transformation

  title={eIF4E – from translation to transformation},
  author={Ya{\"e}l Mamane and Emmanuel Petroulakis and Liwei Rong and Kaori Yoshida and Lian Wee Ler and Nahum Sonenberg},
Over the years, studies have focused on the transcriptional regulation of oncogenesis. More recently, a growing emphasis has been placed on translational control. The Ras and Akt signal transduction pathways play a critical role in regulating mRNA translation and cellular transformation. The question arises: How might the Ras and Akt signaling pathways affect translation and mediate transformation? These pathways converge on a crucial effector of translation, the initiation factor eIF4E, which… CONTINUE READING
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