eFGF regulates Xbra expression during Xenopus gastrulation.

  title={eFGF regulates Xbra expression during Xenopus gastrulation.},
  author={Harry V. Isaacs and Mary E Pownall and Jonathan M. W. Slack},
  journal={The EMBO journal},
  volume={13 19},
We show that, in addition to a role in mesoderm induction during blastula stages, FGF signalling plays an important role in maintaining the properties of the mesoderm in the gastrula of Xenopus laevis. eFGF is a maternally expressed secreted Xenopus FGF with potent mesoderm-inducing activity. However, it is most highly expressed in the mesoderm during gastrulation, suggesting a role after the period of mesoderm induction. eFGF is inhibited by the dominant negative FGF receptor. Embryos… CONTINUE READING
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