eFGF is required for activation of XmyoD expression in the myogenic cell lineage of Xenopus laevis.

@article{Fisher2002eFGFIR,
  title={eFGF is required for activation of XmyoD expression in the myogenic cell lineage of Xenopus laevis.},
  author={M. E. Fisher and Harry V. Isaacs and Mary E Pownall},
  journal={Development},
  year={2002},
  volume={129 6},
  pages={1307-15}
}
This paper addresses the molecular mechanisms that regulate the transcriptional activation of the myogenic regulatory factor XmyoD in the skeletal muscle lineage of Xenopus laevis. Using antisense morpholino oligonucleotide-mediated inhibition, we show that the signalling molecule embryonic fibroblast growth factor (eFGF), which is the amphibian homologue of FGF4, is necessary for the initial activation of XmyoD transcription in myogenic cells. We demonstrate that eFGF can activate the… CONTINUE READING
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