eEF1A mediates the nuclear export of SNAG-containing proteins via the Exportin5-aminoacyl-tRNA complex.

@article{Mingot2013eEF1AMT,
  title={eEF1A mediates the nuclear export of SNAG-containing proteins via the Exportin5-aminoacyl-tRNA complex.},
  author={Jos{\'e} Manuel Mingot and Sonia Vega and A Barbado Cano and Francisco Portillo and M Angela Nieto},
  journal={Cell reports},
  year={2013},
  volume={5 3},
  pages={727-37}
}
Exportin5 mediates the nuclear export of double-stranded RNAs, including pre-microRNAs, adenoviral RNAs, and tRNAs. When tRNAs are aminoacylated, the Exportin5-aminoacyl (aa)-tRNA complex recruits and coexports the translation elongation factor eEF1A. Here, we show that eEF1A binds to Snail transcription factors when bound to their main target, the E-cadherin promoter, facilitating their export to the cytoplasm in association with the aa-tRNA-Exportin5 complex. Snail binds to eEF1A through the… CONTINUE READING
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